However, the mechanistic links between PARK2 mutations and dopaminergicneuron degeneration are unclear.
2
Different stem cells even yield two identical series of dopaminergicneuron types, but with unrelated sister neurons.
3
Patients with Parkinson's disease have reduced reward sensitivity related to dopaminergicneuron loss, which is associated with impairments in reinforcement learning.
4
What's more, the rate of neurogenesis is similar to the rate of dopaminergicneuron loss reported using a chronic, systemic inflammatory response mouse model.
5
Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergicneuron death may act together to increase the risk of PD considerably.
Uso de dopaminergic neurons em inglês
1
Our findings suggest a specific pathological effect of HNE-aSyn on dopaminergicneurons.
2
Here we studied dopaminergicneurons derived from patients with idiopathic and familial PD.
3
Cocaine enhanced the levels of striatal dopamine produced by electrical stimulation of dopaminergicneurons.
4
Each was integrated into the host striatum and contained dense clusters of dopaminergicneurons.
5
Several people with Parkinson's disease have been treated with intrastriatal grafts of fetal dopaminergicneurons.
6
Critical for the production of dopaminergicneurons after RA induction was the post-induction plating conditions used.
7
All identified dopaminergicneurons were of type I and all GABAergic neurons were of type II.
8
Lastly, we observed dopaminergicneurons in wild type worms and in hsp-70 mutants following Mn treatment.
9
No dopaminergicneurons were detected if cells were plated in serum-free media optimized for neuronal survival.
10
Manganese (Mn) is known to pass across the blood-brain barrier and interact with dopaminergicneurons.
11
Loss of this function may underlie the degeneration of nigral dopaminergicneurons in patients with Parkin mutations.
12
As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergicneurons.
13
Induction of newly dopaminergicneurons through exposure to the short-day photoperiod rescued the behavioral consequences of lesions.
14
The degree of rotational recovery was highly correlated to the number of surviving transplanted porcine dopaminergicneurons.
15
Parkinson's disease is characterized by a progressive and selective loss of dopaminergicneurons in the substantia nigra.
16
In addition, acupuncture therapy decreases cell death processes and attenuates oxidative stress to substantia nigra dopaminergicneurons.